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Article

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.

Molecular autism - 13 Jan 2021

Martin Lorenzo Sandra, Nalesso Valérie, Chevalier Claire, Birling Marie-Christine, Herault Yann

Abstract excerpt

BACKGROUND: Gene copy number variants play an important role in the occurrence of neurodevelopmental disorders. Particularly, the deletion of the 16p11.2 locus is associated with autism spectrum disorder, intellectual disability, and several other features. Earlier studies highlighted the implication of Kctd13 genetic imbalance in 16p11.2 deletion through the regulation of the RHOA pathway. METHODS: Here, we...

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Identifiers

PMID: 33436060
DOI: 10.1186/s13229-020-00405-7
PMCID: PMC7805198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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