Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.

doi:10.1038/s41380-018-0025-5

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Article

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.

Molecular psychiatry - 1 Sept 2019

Richter Melanie, Murtaza Nadeem, Scharrenberg Robin, White Sean H, Johanns Ole, Walker Susan, Yuen Ryan K C, Schwanke Birgit, Bedürftig Bianca, Henis Melad, Scharf Sarah, Kraus Vanessa, Dörk Ronja, Hellmann Jakob, Lindenmaier Zsuzsa, Ellegood Jacob, Hartung Henrike, Kwan Vickie, Sedlacik Jan, Fiehler Jens, Schweizer Michaela, Lerch Jason P, Hanganu-Opatz Ileana L, Morellini Fabio, Scherer Stephen W, Singh Karun K, Calderon de Anda Froylan

Abstract excerpt

Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to NDDs is unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and knockout (KO) mice and found gene dosage-dependent impairments in cognition,...

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Identifiers

PMID: 29467497
DOI: 10.1038/s41380-018-0025-5
PMCID: PMC6756231

Genes

TAOK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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