Article

Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responses

2025-09-21

Abstract excerpt

Metastatic colonization of distant tissues is responsible for most cancer deaths, yet while this colonization is typically preceded by lymph node (LN) metastasis, the clonal and functional relationships between metastases in these tissues remain unclear. Reconstruction of metastatic phylogenies in mouse models and patients suggests that LN and distant organ metastases are often seeded by independent clones, yet no...

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Literature Corpus work: 5a50f1b7-21a8-5399-a7e3-582830f3c791
DOI: 10.1101/2025.09.18.677123

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