Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal tracing reveals diverse patterns of response to immune checkpoint blockade

15 Oct 2020

Abstract excerpt

BACKGROUND: Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of ICB response, but elucidating the molecular and cellular drivers of resistance for individual tumors remains challenging. We sought to determine whether a tumor with defined genetic background...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33059736
DOI: 10.1186/s13059-020-02166-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal tracing reveals diverse patterns of response to immune checkpoint blockadePMID 33059736Read ↗

LAG-3 blockade reactivates the CD8 <sup>+</sup> T cell expansion program to re-expand contracted clones in the tumorSemantic proximity Read ↗

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in miceSemantic proximity Read ↗

Early clonal expansion of tumor-infiltrating lymphocytes predicts response to immune checkpoint therapySemantic proximity Read ↗

Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responsesSemantic proximity Read ↗

Multi-model preclinical platform predicts clinical response of melanoma to immunotherapySemantic proximity Read ↗

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.Semantic proximity Read ↗

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in MelanomaSemantic proximity Read ↗

Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics.Semantic proximity Read ↗

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer.Semantic proximity Read ↗

Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myelomaSemantic proximity Read ↗

A Diversity Outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitorsSemantic proximity Read ↗

Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.