Article

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

2025-02-05

Abstract excerpt

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and clonal analyses have revealed substantial functional and molecular heterogeneity within this compartment, challenging the notion that self-renewal is inherently tied to balanced, multi-lineage blood production. Howeve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a0b1736-ec4b-526f-a513-962773e8ad67
DOI: 10.1101/2025.02.04.636388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cellsDOI 10.1101/2025.02.04.636388Read

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsetsSemantic proximity Read

Stem cell heterogeneity: implications for aging and regenerative medicineSemantic proximity Read

Predicting clonal self-renewal and extinction of hematopoietic stem cellsSemantic proximity Read

Output without input: the lifelong productivity of hematopoietic stem cells.Semantic proximity Read

Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of “Super” transplantabilitySemantic proximity Read

Tracking Human HSCs and MPPs in Mice Reveals Distinct Clonal Dynamics and Responses to Pre-transplant ConditioningSemantic proximity Read

A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesisSemantic proximity Read

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution PhasesSemantic proximity Read

<i>Ex vivo</i> Expansion Potential of Murine Hematopoietic Stem Cells: A Rare Property Only Partially Predicted by PhenotypeSemantic proximity Read

Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype.Semantic proximity Read

Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis.Semantic proximity Read

Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential.Semantic proximity Read