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Predicting clonal self-renewal and extinction of hematopoietic stem cells

28 Feb 2011

Abstract excerpt

A single hematopoietic stem cell (HSC) can generate a clone, consisting of daughter HSCs and differentiated progeny, which can sustain the hematopoietic system of multiple hosts for a long time. At the same time, this massive expansion potential must be restrained to prevent abnormal, leukemic proliferation. We used an interdisciplinary approach, combining transplantation assays with mathematical and...

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PMID: 21368169
DOI: 10.1073/pnas.1011414108

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