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Article

Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype.

eLife - 6 Mar 2024

Zhang Qinyu, Olofzon Rasmus, Konturek-Ciesla Anna, Yuan Ouyang, Bryder David

Abstract excerpt

The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After 3 weeks of culture, only 0.1% of cells exhibited the input HSC phenotype, but these accounted for almost all functional long-term HSC activity. Input HSCs displayed varying potential for...

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Identifiers

PMID: 38446538
DOI: 10.7554/eLife.91826
PMCID: PMC10942641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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