Article

<i>Ex vivo</i> Expansion Potential of Murine Hematopoietic Stem Cells: A Rare Property Only Partially Predicted by Phenotype

2022-06-20

Abstract excerpt

<h4>ABSTRACT</h4> The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After three weeks of culture, only 0.1% of cells exhibited the input HSC phenotype, but these accounted for almost all functional long-term HSC activity. Input HSCs displayed...

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Literature Corpus work: 3e83b1db-fa9b-5d90-8490-8db6499c3081
DOI: 10.1101/2022.06.20.496822

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