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Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of “Super” transplantability

21 Apr 2025

Abstract excerpt

ABSTRACT: Hematopoietic stem cells (HSCs) are heterogeneous, and the quality of HSCs-that is, transplantability-is a key determinant for posttransplant hematopoietic reconstitution. However, molecular modalities of high-potency HSCs with superior transplantability still remain poorly understood. Here, we conducted large-scale single-clone serial-transplant experiments and tracked descendant cells of 288 HSC...

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PMID: 40258179
DOI: 10.1182/blood.2024027872

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