Article
Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential.
Nature cell biology - 1 Jun 2018
Knapp David J H F, Hammond Colin A, Hui Tony, van Loenhout Marijn T J, Wang Fangwu, Aghaeepour Nima, Miller Paul H, Moksa Michelle, Rabu Gabrielle M, Beer Philip A, Pellacani Davide, Humphries R Keith, Hansen Carl, Hirst Martin, Eaves Connie J
Abstract excerpt
Elucidation of the identity and diversity of mechanisms that sustain long-term human blood cell production remains an important challenge. Previous studies indicate that, in adult mice, this property is vested in cells identified uniquely by their ability to clonally regenerate detectable, albeit highly variable levels and types, of mature blood cells in serially transplanted recipients. From a multi-parameter...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.