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Mendelian randomization and transcriptome analysis identified immune-related biomarkers for osteoarthritis.

Frontiers in immunology - 1 Jan 2024

Pang Wei-Wei, Cai Yi-Sheng, Cao Chong, Zhang Fu-Rong, Zeng Qin, Liu Dan-Yang, Wang Ning, Qu Xiao-Chao, Chen Xiang-Ding, Deng Hong-Wen, Tan Li-Jun

Abstract excerpt

Background: The immune microenvironment assumes a significant role in the pathogenesis of osteoarthritis (OA). However, the current biomarkers for the diagnosis and treatment of OA are not satisfactory. Our study aims to identify new OA immune-related biomarkers to direct the prevention and treatment of OA using multi-omics data. Methods: The discovery dataset integrated the GSE89408 and GSE143514 datasets to...

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Biomarkers
Gene Expression Profiling
Genome-Wide Association Study
Machine Learning
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 38680491
DOI: 10.3389/fimmu.2024.1334479
PMCID: PMC11045931

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FCER1G

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