Article

For antibody sequence generative modeling, mixture models may be all you need

2024-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Antibody therapeutic candidates must exhibit not only tight binding to their target but also good developability properties, especially low risk of immunogenicity. In this work, we fit a simple generative model, SAM, to sixty million human heavy and seventy million human light chains. We show that the probability of a sequence calculated by the model distinguishes human sequences from other spec...

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Literature Corpus work: 83b791f4-5a28-585a-8bea-9598ef3dc7c4
DOI: 10.1101/2024.01.27.577555

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