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Article

Addressing the antibody germline bias and its effect on language models for improved antibody design.

Bioinformatics (Oxford, England) - 1 Nov 2024

Olsen Tobias H, Moal Iain H, Deane Charlotte M

Abstract excerpt

MOTIVATION: The versatile binding properties of antibodies have made them an extremely important class of biotherapeutics. However, therapeutic antibody development is a complex, expensive, and time-consuming task, with the final antibody needing to not only have strong and specific binding but also be minimally impacted by developability issues. The success of transformer-based language models in protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Monoclonal and Polyclonal Antibodies Research

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Source

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Identifiers

PMID: 39460949
DOI: 10.1093/bioinformatics/btae618
PMCID: PMC11543624

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