Article

Phenome-wide analysis of<i>APOL1</i>risk variants reveals associations between one combination of haplotypes and multiple disease phenotypes in addition to chronic kidney disease

2023-02-23

Abstract excerpt

<h4>Background</h4> Infectious diseases are a major driving force of natural selection. One human gene associated with strong evolutionary selection is APOL1 . Two APOL1 variants, G1 and G2, emerged in sub-Saharan Africa in the last 10,000 years, possibly due to protection from the fatal African sleeping sickness, analogous to Plasmodium -driven selection of the sickle-cell trait. As homozygosity for the HbS allel...

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Literature Corpus work: 59ec9b65-6c3a-5eb5-b46e-0d383e5a1fb6
DOI: 10.1101/2023.02.19.23285950

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