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Article

APOL1 Nephropathy: A Population Genetics and Evolutionary Medicine Detective Story.

Seminars in nephrology - 1 Nov 2017

Kruzel-Davila Etty, Wasser Walter G, Skorecki Karl

Abstract excerpt

Common DNA sequence variants rarely have a high-risk association with a common disease. When such associations do occur, evolutionary forces must be sought, such as in the association of apolipoprotein L1 (APOL1) gene risk variants with nondiabetic kidney diseases in populations of African ancestry. The variants originated in West Africa and provided pathogenic resistance in the heterozygous state that led to...

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Source

Identifiers

PMID: 29110756
DOI: 10.1016/j.semnephrol.2017.07.002

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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