APOL1 variants G1, G2 and N264K affect APOL1 plasma protein concentration: a UK Biobank study

Abstract excerpt

<h4>Background</h4> APOL1 variants G1 and G2 are common in populations with recent sub-Saharan African ancestry. They are known to influence health conditions: most notably being associated with protection from human African trypanosomiasis and increased risk of susceptibility to chronic kidney disease. Association studies have often considered G1 and G2 as equivalent, however we recently presented evidence of sub...

Topics

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• Africa South of the Sahara
• Apolipoprotein L1
• Apolipoproteins
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genotype
• Renal Insufficiency, Chronic
• Risk Factors

Identifiers and source

Literature Corpus work

55e53f79-b052-52db-867a-6841b18e4f89

DOI

10.1101/2024.02.28.24303461