Article

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

2021-03-02

Abstract excerpt

Decidual remodelling of midluteal endometrium leads to a short implantation window after which the uterine mucosa either breaks down or is transformed into a robust matrix that accommodates the placenta throughout pregnancy. To gain insights into the underlying mechanisms, we established and characterised endometrial assembloids, consisting of gland organoids and primary stromal cells. Single-cell transcriptomics...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59e08d9b-e768-5b65-a242-59dfc62032c5
DOI: 10.1101/2021.03.02.433560

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloidsDOI 10.1101/2021.03.02.433560Read

Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cellsSemantic proximity Read

Senescence of stromal cells contributes to endometrium dysfunction and embryo implantation failureSemantic proximity Read

Single cell mapping of the human endometrium and first trimester decidua identifies distinct epithelial and stromal cell contributions to fertilitySemantic proximity Read

Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoidsSemantic proximity Read

An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometriumSemantic proximity Read

Molecular basis of senescence transmitting in the population of human endometrial stromal cellsSemantic proximity Read

Aging promotes accumulation of senescent and multiciliated cells in human endometrial epitheliumSemantic proximity Read

Aging affects ciliated cells development in the human endometrial epitheliumSemantic proximity Read

Generation of Human Endometrial Assembloids with a Luminal Epithelium using Air–Liquid Interface Culture MethodsSemantic proximity Read

The endoplasmic reticulum protein HSPA5/BiP is essential for decidual transformation of human endometrial stromal cellsSemantic proximity Read

Uterine organoids reveal insights into epithelial specification and plasticity in development and diseaseSemantic proximity Read

Cellular senescence in reproduction: a two-edged sword†.Semantic proximity Read