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Article

Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells

6 May 2022

Abstract excerpt

STUDY QUESTION: What are the consequences of endometrial stromal cell (EnSC) senescence for endometrial function? SUMMARY ANSWER: Senescence of EnSC contributes to impaired endometrial decidualization and impaired interaction with trophoblast cells but application of senomorphics diminishes the adverse effects of senescent EnSC on decidualization and implantation. WHAT IS KNOWN ALREADY: A prolonged and highly...

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PMID: 35604371
DOI: 10.1093/humrep/deac112

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