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The endoplasmic reticulum protein HSPA5/BiP is essential for decidual transformation of human endometrial stromal cells

29 Oct 2024

Abstract excerpt

Decidualization denotes the process of inflammatory reprogramming of endometrial stromal cells (EnSC) into specialized decidual cells (DC). During this process, EnSC are subjected to endoplasmic reticulum (ER) stress as well as acute cellular senescence. Both processes contribute to the proinflammatory mid-luteal implantation window and their dysregulation has been implicated in reproductive failure. Here, we...

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PMID: 39472623
DOI: 10.1038/s41598-024-76241-z

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