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Uterine organoids reveal insights into epithelial specification and plasticity in development and disease

30 Jan 2025

Abstract excerpt

Understanding how epithelial cells in the female reproductive tract (FRT) differentiate is crucial for reproductive health, yet the underlying mechanisms remain poorly defined. At birth, FRT epithelium is highly malleable, allowing differentiation into various epithelial types, but the regulatory pathways guiding these early cell fate decisions are unclear. Here, we use neonatal mouse endometrial organoids and...

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PMID: 39883834
DOI: 10.1073/pnas.2422694122

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