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Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids

23 Feb 2024

Abstract excerpt

INTRODUCTION: Advanced maternal age is associated with reduced implantation and pregnancy rates, yet the underlying mechanisms remain poorly understood, and research models are limited. OBJECTIVES: Here, we aim to elucidate the impacts of senescence on implantation ability by employing blastoids to construct a novel research model. METHODS: We used a novel three-dimensional system with totipotent blastomere-like...

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PMID: 38402947
DOI: 10.1016/j.jare.2024.02.011

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