Article

BMP4 induces a p21-dependent cell state shift in glioblastoma linking mesenchymal transition to senescence

2024-06-24

Abstract excerpt

Bone morphogenetic protein 4 (BMP4) has emerged as a potential glioblastoma therapy due to its anti- proliferative effect via SOX2 downregulation and differentiation promotion. However, BMP4 responses vary across and within tumors. Our previous data indicate that BMP4 induces transition to a mesenchymal-like cell state. Mesenchymal transition is associated with therapy-resistance and tumor recurrence, as is senesc...

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Identifiers and source

Literature Corpus work: 598d92d6-59d1-5a3c-bb88-26a9dafba58c
DOI: 10.1101/2024.06.20.599819

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