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Article

SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis

5 Feb 2019

Abstract excerpt

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results show that SIX1 also acts as a repressor of cell senescence, an antiproliferative response with a key role in tumor suppression, among other physiological and pathological settings. Here, we set to study the impact of SIX1 gain of function in transformation and tumorigenesis of fibroblasts, in connection with...

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Share to Epigenetics and DNA Methylation
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Share to Telomeres, Telomerase, and Senescence

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PMID: 30723235
DOI: 10.1038/s41598-018-38176-0

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