Article

Canonical BMP2/4 signaling degrades SOX2 in glioblastoma propagating cells

2022-02-04

Abstract excerpt

<h4>ABSTRACT</h4> The effect of Bone Morphogenetic Proteins (BMPs) on glioblastoma propagation cells (GPCs) is being debated [1-5]. We observed that exposure of GPCs to BMP2/4 initiates a rapid proteasomal degradation of the pluripotency factor SOX2 followed by the differentiation of GPCs into glial cells using 5 primary human glioblastoma lines tested. Enforced expression of SOX2 in GPCs antagonized BMP2/4-induc...

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Literature Corpus work: 018dbc42-2828-5878-84b3-943a402b1117
DOI: 10.1101/2022.02.03.479056

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