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BMP signaling in cancer stemness and differentiation

5 Dec 2023

Abstract excerpt

The BMP (Bone morphogenetic protein) signaling pathway plays a central role in metazoan biology, intricately shaping embryonic development, maintaining tissue homeostasis, and influencing disease progression. In the context of cancer, BMP signaling exhibits context-dependent dynamics, spanning from tumor suppression to promotion. Cancer stem cells (CSCs), a modest subset of neoplastic cells with stem-like...

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PMID: 38049682
DOI: 10.1186/s13619-023-00181-8

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