Article
Senescence-associated reprogramming promotes cancer stemness.
Nature - 4 Jan 2018
Milanovic Maja, Fan Dorothy N Y, Belenki Dimitri, Däbritz J Henry M, Zhao Zhen, Yu Yong, Dörr Jan R, Dimitrova Lora, Lenze Dido, Monteiro Barbosa Ines A, Mendoza-Parra Marco A, Kanashova Tamara, Metzner Marlen, Pardon Katharina, Reimann Maurice, Trumpp Andreas, Dörken Bernd, Zuber Johannes, Gronemeyer Hinrich, Hummel Michael, Dittmar Gunnar, Lee Soyoung, Schmitt Clemens A
Abstract excerpt
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the further expansion of (pre-)malignant cells. Key signalling components of the senescence machinery, such as p16INK4a, p21CIP1 and p53, as well as trimethylation of lysine 9 at histone H3 (H3K9me3), also operate as critical regulators of stem-cell functions (which are collectively termed 'stemness'). In cancer cells, a gain of...
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