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Article

Integrative transcriptomic profiling links telomere dysfunction to cGAS-STING activation in heart failure signatures in mice and humans.

Cardiovascular research - 26 Mar 2026

Brandt Moritz, Khraisat Sana'a, Luo Qi, Mayerle Megan, Raaz Uwe, Tsao Phil, Münzel Thomas, Lurz Philipp, Wenzel Philip, Blau Helen M

Abstract excerpt

AIMS: Cardiomyocyte telomere shortening is evident during heart failure pathogenesis. Conversely, mice with engineered telomerase deficiency develop myocardial dysfunction accompanied by p53 activation and mitochondrial repression. We aimed to address fundamental gaps in knowledge: whether cardiac dysfunction in mice lacking telomerase components arises from myocardial-intrinsic effects or systemic consequences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41571554
DOI: 10.1093/cvr/cvag013
PMCID: PMC13020247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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