Back to search

Article

A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females

2026-07-16

Abstract excerpt

<title>Abstract</title> <p> Alzheimer's disease (AD) disproportionately affects women, who exhibit greater vulnerability to Tau pathology and neuroinflammation. The precise mechanisms underlying this vulnerability remain elusive, although sex hormones are thought to play a pivotal role. Here, we report that supplementation with the non-aromatizable androgen dihydrotestosterone (DHT) exacerbates Tau pathology in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5932f967-760e-5372-8614-039e9fb0e926
DOI
10.21203/rs.3.rs-10286730/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A non-canonical androgen signaling pathway drives microglial activation and tau pathology in femalesDOI 10.21203/rs.3.rs-10286730/v1
Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosisSemantic proximity
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s diseaseSemantic proximity
The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways.Semantic proximity
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s diseaseSemantic proximity
Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s diseaseSemantic proximity
AD-linked R47H- <i>TREM2</i> mutation induces disease-enhancing proinflammatory microglial states in mice and humansSemantic proximity
Identification of Progesterone-Associated Gene Signatures in Men with Alzheimer’s Disease Using Public Transcriptomic DataSemantic proximity
Altered Metabolism and DAM-signatures in Female Brains and Microglia with AgingSemantic proximity
Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive PerformanceSemantic proximity
Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive PerformanceSemantic proximity
Spatiotemporal Characterization of Amyloidosis-Associated Microglial States Reveals Sex Difference in Early Plaque FormationSemantic proximity
Shaping Microglial Phenotypes Through Estrogen Receptors: Relevance to Sex-Specific Neuroinflammatory Responses to Brain Injury and Disease.Semantic proximity
Select a neighboring publication to make it the new centre.