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Article

Identification of Progesterone-Associated Gene Signatures in Men with Alzheimer’s Disease Using Public Transcriptomic Data

2026-02-19

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction</bold> Alzheimer’s disease (AD) exhibits marked molecular heterogeneity, with increasing evidence that sex-specific biological mechanisms influence disease onset and progression. Progesterone is a neuroactive steroid involved in mitochondrial regulation, neuroinflammation, and synaptic function; however, its transcriptional regulation in men with AD remains insuffi...

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Literature Corpus work
02d3983e-79a4-56c5-ad7c-6a329386871f
DOI
10.21203/rs.3.rs-8904728/v1
Open publication

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