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High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging

2026-02-11

Abstract excerpt

Huntington’s disease (HD) is a repeat-associated neurodegenerative disorder traditionally characterized by toxic protein pathology resulting from expanded CAG repeats in the huntingtin (HTT) gene. In recent years, however, studies have identified repeat expansion–driven RNA pathology as an additional and potentially independent contributor to disease. In particular, mutant HTT transcripts containing expanded CAG r...

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Literature Corpus work
592a7b9b-1d35-5a63-b7c6-7cb596d1ab99
DOI
10.64898/2026.02.09.704866
Open publication

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High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imagingDOI 10.64898/2026.02.09.704866
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