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Article

Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study.

PloS one - 1 Jan 2015

Carty Nikisha, Berson Nadège, Tillack Karsten, Thiede Christina, Scholz Diana, Kottig Karsten, Sedaghat Yalda, Gabrysiak Christina, Yohrling George, von der Kammer Heinz, Ebneth Andreas, Mack Volker, Munoz-Sanjuan Ignacio, Kwak Seung

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. Major pathological hallmarks of HD include inclusions of mutant huntingtin (mHTT) protein, loss of neurons predominantly in the caudate nucleus, and atrophy of multiple brain regions. However, the early sequence of histological events that manifest in region- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25859666
DOI: 10.1371/journal.pone.0123527
PMCID: PMC4393127

Genes

HTT

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Related research

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Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study.PMID 25859666Read ↗

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