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Expression analysis of Huntington disease mouse models reveals robust striatum disease signatures

2022-02-08

Abstract excerpt

Huntington’s disease is caused by expanded trinucleotide repeats in the huntingtin gene (HTT), and a higher number of repeats is associated with an earlier age of disease onset. Although the causative gene has been identified, its connections to the observed disease phenotypes is still unclear. Mouse models engineered to contain increasing numbers of trinucleotide repeats were sacrificed at different ages to detec...

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Literature Corpus work
667df018-b47c-596a-9a92-ebf7c5b585b3
DOI
10.1101/2022.02.04.479180
Open publication

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Expression analysis of Huntington disease mouse models reveals robust striatum disease signaturesDOI 10.1101/2022.02.04.479180
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