High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

doi:10.1093/hmg/ddx006

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

Human molecular genetics - 1 Mar 2017

Ament Seth A, Pearl Jocelynn R, Grindeland Andrea, St Claire Jason, Earls John C, Kovalenko Marina, Gillis Tammy, Mysore Jayalakshmi, Gusella James F, Lee Jong-Min, Kwak Seung, Howland David, Lee Min Young, Baxter David, Scherler Kelsey, Wang Kai, Geman Donald, Carroll Jeffrey B, MacDonald Marcy E, Carlson George, Wheeler Vanessa C, Price Nathan D, Hood Leroy E

Abstract excerpt

Huntington's disease is a dominantly inherited neurodegenerative disease caused by the expansion of a CAG repeat in the HTT gene. In addition to the length of the CAG expansion, factors such as genetic background have been shown to contribute to the age at onset of neurological symptoms. A central challenge in understanding the disease progression that leads from the HD mutation to massive cell death in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Genetic Background

Share to Genomic Instability

Share to Huntingtin Protein

Share to Huntington Disease

Share to Transcriptome

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 28334820
DOI: 10.1093/hmg/ddx006
PMCID: PMC6075528

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.PMID 28334820Read ↗

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.Semantic proximity Read ↗

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomicsSemantic proximity Read ↗

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Semantic proximity Read ↗

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity Read ↗

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington diseaseSemantic proximity Read ↗

Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington’s DiseaseSemantic proximity Read ↗

High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imagingSemantic proximity Read ↗

Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.Semantic proximity Read ↗

Expression analysis of Huntington disease mouse models reveals robust striatum disease signaturesSemantic proximity Read ↗

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neuronsSemantic proximity Read ↗

Cell-specific transcription dysregulation in human Huntington’s disease-positive developing striatumSemantic proximity Read ↗

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.