Article

Utility of polygenic embryo screening for disease depends on the selection strategy

2020-11-06

Abstract excerpt

Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of expected outcomes. Here we predict, based on the liability threshold model, the expected reduction in complex disease risk following polygenic embryo screening for a single disease. Our main finding is that a strong determinant of...

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Literature Corpus work: 59188c09-ad0c-5daa-ae63-ea0349cfcec9
DOI: 10.1101/2020.11.05.370478

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