Article

Prioritizing embryos with lower homozygosity is expected to reduce disease risk in children of related individuals undergoing preimplantation genetic testing

2026-06-04

Abstract excerpt

Consanguinity is a reproductive union between individuals who share a recent common ancestor. These unions are common in many regions of the world and increase the burden of rare recessive disorders by elevating autozygosity in offspring. Current reproductive genetic screening focuses on a limited set of known pathogenic variants, leaving most recessive risk unaddressed. Here we argue that embryo-level autozygosit...

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Literature Corpus work: 41dc1939-77ed-5437-b77f-e50253ce0ef3
DOI: 10.64898/2026.05.30.26354526

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