Article

Early reduction and impaired targeting of myelin-associated glycoprotein to myelin membranes in Huntington’s disease

2025-10-15

Abstract excerpt

<h4>Background</h4> Huntington’s disease (HD) is a hereditary life-threatening disease marked by progressive neuronal loss and atrophy of grey matter structures, particularly the caudate putamen. Brain imaging studies have revealed that the degradation of the white matter occurs many years prior to symptomatic onset and neuronal loss, suggesting that the decay of brain white matter is an active contributor to the...

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Literature Corpus work: 59132791-8a9f-55e6-a198-1394a2dcee32
DOI: 10.1101/2025.10.15.682629

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