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Insights into White Matter Defect in Huntington’s Disease

26 Oct 2022

Abstract excerpt

Huntington's disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene that is translated to an expanded polyglutamine (PolyQ) repeat in huntingtin protein. HD is characterized by mood swings, involuntary movement, and cognitive decline in the late disease stage. HD patients often die 15-20 years after disease onset....

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PMID: 36359783
DOI: 10.3390/cells11213381

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