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Article

Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age.

Neuro-degenerative diseases - 1 Jan 2018

Vidinská Daniela, Vochozková Petra, Šmatlíková Petra, Ardan Taras, Klíma Jiří, Juhás Štefan, Juhásová Jana, Bohuslavová Božena, Baxa Monika, Valeková Ivona, Motlík Jan, Ellederová Zdenka

Abstract excerpt

BACKGROUND: Huntington disease (HD) is an incurable neurodegenerative disease caused by the expansion of a polyglutamine sequence in a gene encoding the huntingtin (Htt) protein, which is expressed in almost all cells of the body. In addition to small animal models, new therapeutic approaches (including gene therapy) require large animal models as their large brains are a more realistic model for translational...

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PMID: 29870995
DOI: 10.1159/000488592

Genes

ACBD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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