Article
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Neuron - 5 Apr 2017
Gasset-Rosa Fatima, Chillon-Marinas Carlos, Goginashvili Alexander, Atwal Ranjit Singh, Artates Jonathan W, Tabet Ricardos, Wheeler Vanessa C, Bang Anne G, Cleveland Don W, Lagier-Tourenne Clotilde
Abstract excerpt
Onset of neurodegenerative disorders, including Huntington's disease, is strongly influenced by aging. Hallmarks of aged cells include compromised nuclear envelope integrity, impaired nucleocytoplasmic transport, and accumulation of DNA double-strand breaks. We show that mutant huntingtin markedly accelerates all of these cellular phenotypes in a dose- and age-dependent manner in cortex and striatum of mice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.