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Article

Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2016

Zhao Ting, Hong Yan, Li Shihua, Li Xiao-Jiang

Abstract excerpt

UNLABELLED: In neurodegenerative diseases caused by misfolded proteins, including Huntington's disease (HD), the neuronal processes and terminals are particularly prone to the accumulation of misfolded proteins, leading to axonal and synaptic dysfunction. This compartment-dependent accumulation can result from either the altered transport of misfolded proteins or impaired protein degradation. Mutant huntingtin...

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Identifiers

PMID: 27511006
DOI: 10.1523/JNEUROSCI.0806-16.2016
PMCID: PMC4978797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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