Back to search

Article

Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

2024-01-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocyte cells. Retinoic acid (RA) plays an important role in regulation of the spatiotemporal development of the embryonic heart. <bold>Methods:</bold> Engineered heart tissues (EHTs) were generat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
59011a75-0578-5e8f-bf82-1fe8a58d258f
DOI
10.21203/rs.3.rs-3782805/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytesDOI 10.21203/rs.3.rs-3782805/v1
Early Inhibition of Retinoic Acid Signaling Rapidly Generates Cardiomyocytes Expressing Ventricular Markers from Human Induced Pluripotent Stem CellsSemantic proximity
Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonistsSemantic proximity
Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmiaSemantic proximity
Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmiaSemantic proximity
Enhanced Generation of Induced Cardiomyocytes Using a Small-Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming.Semantic proximity
Positive inotropic effects of serotonin in atrial EHT: further proof for an atrial phenotype?Semantic proximity
Enrichment differentiation of human induced pluripotent stem cells into sinoatrial node-like cells by combined modulation of BMP, FGF and RA signaling pathwaysSemantic proximity
Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor CellsSemantic proximity
Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cellsSemantic proximity
Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical MappingSemantic proximity
The retinoic acid response is a minor component of the cardiac phenotype in H9c2 myoblast differentiation.Semantic proximity
Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cellsSemantic proximity
Select a neighboring publication to make it the new centre.