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Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

23 Nov 2017

Abstract excerpt

Human pluripotent stem cells (hPSCs) are widely used to study cardiovascular cell differentiation and function. Here, we induced differentiation of hPSCs (both embryonic and induced) to proepicardial/epicardial progenitor cells that cover the heart during development. Addition of retinoic acid (RA) and bone morphogenetic protein 4 (BMP4) promoted expression of the mesodermal marker PDGFRα, upregulated...

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PMID: 29173898
DOI: 10.1016/j.stemcr.2017.10.023

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