Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced Generation of Induced Cardiomyocytes Using a Small-Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming.

Journal of the American Heart Association - 16 Jun 2020

Singh Vivek P, Pinnamaneni Jaya Pratap, Pugazenthi Aarthi, Sanagasetti Deepthi, Mathison Megumi, Wang Kai, Yang Jianchang, Rosengart Todd K

Abstract excerpt

Background Given known inefficiencies in reprogramming of fibroblasts into mature induced cardiomyocytes (iCMs), we sought to identify small molecules that would overcome these barriers to cardiac cell transdifferentiation. Methods and Results We screened alternative combinations of compounds known to impact cell reprogramming using morphologic and functional cell differentiation assays in vitro. After screening...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bridged Bicyclo Compounds, Heterocyclic
Share to Butyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transdifferentiation

Share to Cellular Reprogramming

Share to Histone Deacetylase Inhibitors

Share to Pyrimidinones

Share to Tretinoin

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 32500803
DOI: 10.1161/JAHA.119.015686
PMCID: PMC7429035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced Generation of Induced Cardiomyocytes Using a Small-Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming.PMID 32500803Read ↗

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac ReprogrammingSemantic proximity Read ↗

Cardiac regeneration by direct reprogramming in this decade and beyondSemantic proximity Read ↗

Enhancing Cardiac Reprogramming by Suppressing Specific C-C Chemokine Signaling PathwaysSemantic proximity Read ↗

Early Inhibition of Retinoic Acid Signaling Rapidly Generates Cardiomyocytes Expressing Ventricular Markers from Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Induction of human cardiomyocyte-like cells from fibroblasts by defined factorsSemantic proximity Read ↗

A Novel Transcription Factor Combination for Direct Reprogramming to a Spontaneously Contracting Human Cardiomyocyte-like StateSemantic proximity Read ↗

Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktailsSemantic proximity Read ↗

Molecular barriers to direct cardiac reprogrammingSemantic proximity Read ↗

Direct reprogramming of fibroblasts into cardiomyocytesSemantic proximity Read ↗

Pharmacologically inducing regenerative cardiac cells by small molecule drugsSemantic proximity Read ↗

Conversion of human fibroblasts into functional cardiomyocytes by small moleculesSemantic proximity Read ↗

Cardiomyocyte precursors generated by direct reprogramming and molecular beacon selection attenuate ventricular remodeling after experimental myocardial infarctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.