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Article

The retinoic acid response is a minor component of the cardiac phenotype in H9c2 myoblast differentiation.

BMC genomics - 2 Aug 2023

Campero-Basaldua Carlos, Herrera-Gamboa Jessica, Bernal-Ramírez Judith, Lopez-Moran Silvia, Luévano-Martínez Luis-Alberto, Alves-Figueiredo Hugo, Guerrero Guillermo, García-Rivas Gerardo, Treviño Víctor

Abstract excerpt

The H9c2 myoblast cell line, isolated from the left ventricular tissue of rat, is currently used in vitro as a mimetic for skeletal and cardiac muscle due to its biochemical, morphological, and electrical/hormonal signaling properties. During culture, H9c2 cells acquire a myotube phenotype, where a critical component is the inclusion of retinoic acid (RA). The results from some authors on H9c2 suggested that...

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PMID: 37533008
DOI: 10.1186/s12864-023-09512-0
PMCID: PMC10394869

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