Back to search

Article

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

2023-04-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Atrial fibrillation (AF) is the most common arrhythmia syndrome and causes significant morbidity and mortality. Current therapeutics, however, have limited efficacy. Notably, many therapeutics shown to be efficacious in animal models have not proved effective in humans. Thus, there is a need for a drug screening platform based on human tissue. The aim of this stu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c46b8959-badf-5173-8338-0349357298fc
DOI
10.21203/rs.3.rs-2744099/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmiaDOI 10.21203/rs.3.rs-2744099/v1
Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmiaSemantic proximity
Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonistsSemantic proximity
Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical MappingSemantic proximity
A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CMSemantic proximity
Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytesSemantic proximity
A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM.Semantic proximity
Early Inhibition of Retinoic Acid Signaling Rapidly Generates Cardiomyocytes Expressing Ventricular Markers from Human Induced Pluripotent Stem CellsSemantic proximity
Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitmentSemantic proximity
A Defined and Cost-Efficient Strategy for Generating Functionally Quiescent Human iPSC-Derived Cardiac FibroblastsSemantic proximity
Generation and characterization of functional cardiomyocytes using induced pluripotent stem cells derived from human fibroblastsSemantic proximity
Modeling Atrial Fibrillation through Intermittent Tachypacing-Induced Remodeling in hiPSC-Derived Atrial Cardiomyocytes and Atrial FibroblastSemantic proximity
Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitmentSemantic proximity
Select a neighboring publication to make it the new centre.