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Article

Positive inotropic effects of serotonin in atrial EHT: further proof for an atrial phenotype?

Naunyn-Schmiedeberg's archives of pharmacology - 1 Feb 2026

Sönmez Muhammed, Nandudu Margaret, Brunnbauer Paul, Schulz Carl, Klampe Birgit, Schulze Thomas, Hansen Arne, Eschenhagen Thomas, Christ Torsten

Abstract excerpt

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) cultured in the presence of retinoic acid were proposed as a model for human atrium. Since in the human heart positive inotropic effects of serotonin (5-HT) are restricted to the atrium, we investigated whether the presence of 5-HT responses may distinguish between hiPSC-atrial and ventricular CM. Nonfiltered retinoic acid (1 µM) was used to...

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Identifiers

PMID: 41148253
DOI: 10.1007/s00210-025-04619-5
PMCID: PMC13046593

Genes

HTR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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