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Article

The role of DDAH and ADMA in kidney disease

2014-01-01

Abstract excerpt

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis and elevated plasma levels associate with poor cardiovascular and renal outcomes. The dimethylarginine dimethylaminohydrolase enzymes (DDAHs; 1 and 2) metabolise ADMA. A DDAH1 gene variant associates with higher kidney tissue mRNA expression, lower plasma ADMA but counter-intuitively, a steeper rate of eGFR decline. This i...

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Literature Corpus work
58f3b276-ed80-5946-8990-b42bc3991814
DOI
10.25560/24541
Open publication

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