Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.

doi:10.1161/ATVBAHA.110.222638

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Article

Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2011

Hu Xinli, Atzler Dorothee, Xu Xin, Zhang Ping, Guo Haipeng, Lu Zhongbing, Fassett John, Schwedhelm Edzard, Böger Rainer H, Bache Robert J, Chen Yingjie

Abstract excerpt

OBJECTIVE: The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA). METHODS AND RESULTS: We generated a global-DDAH1 gene-deficient (DDAH1(-/-)) mouse strain to examine the role of DDAH1 in ADMA and l-NMMA degradation and the...

Topics

Amidohydrolases
Animals
Arginine
Blood Pressure
Cardiovascular Diseases
Cells, Cultured
Endothelial Cells
Enzyme Inhibitors
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypertension

Infusion Pumps, Implantable

Male

Mice

Mice, 129 Strain

Mice, Knockout

NG-Nitroarginine Methyl Ester

Nitric Oxide

Source

Open in PubMed Open full text

Identifiers

PMID: 21493890
DOI: 10.1161/ATVBAHA.110.222638
PMCID: PMC3117037

Genes

DDAH1
DDAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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