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Article

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease.

Atherosclerosis - 1 Nov 2013

Sesti Giorgio, Mannino Gaia Chiara, De Lorenzo Carlo, Greco Annalisa, Sciacqua Angela, Marini Maria A, Andreozzi Francesco, Perticone Francesco

Abstract excerpt

OBJECTIVE: Studies reported a relationship between elevated asymmetric dimethylarginine (ADMA) concentrations and adverse renal outcomes. There is evidence that the rs9267551 variant in the DDAH2 gene has a functional impact with the C allele having a higher transcriptional activity resulting in increased expression of DDAH2 in endothelial cells and lower plasma ADMA levels in C allele carriers. METHODS: To...

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Source

Identifiers

PMID: 24125425
DOI: 10.1016/j.atherosclerosis.2013.08.041

Genes

DDAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease.PMID 24125425Read ↗

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