Article
ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis.
Kidney & blood pressure research - 1 Jan 2012
Tanhäuserová Veronika, Tomandl Josef, Pácal Lukáš, Klepárník Martin, Malúšková Denisa, Bartáková Vendula, Kuricová Katarína, Rehořová Jitka, Stěpánková Soňa, Svojanovský Jan, Olšovský Jindřich, Bělobrádková Jana, Krusová Darja, Jurajda Michal, Mužík Jan, Pavlík Tomáš, Kaňková Kateřina
Abstract excerpt
BACKGROUND/AIMS: Complex interplay of genetic and (patho)physiological factors influence availability of nitric oxide during the development and progression of diabetic complications. We assessed predictive value of commonly studied methylated asymmetric and symmetric dimethylarginines (ADMA and SDMA) and selected single nucleotide polymorphisms (SNPs) in dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2...
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